SUBCUTANEOUS SARILUMAB FOR THE TREATMENT OF HOSPITALIZED PATIENTS WITH MODERATE TO SEVERE COVID19 DISEASE: A PRAGMATIC, EMBEDDED RANDOMIZED CLINICAL TRIAL.

Importance and objectiveThe aim of this pragmatic, embedded, adaptive trial was to measure the effectiveness of the subcutaneous anti-IL-6R antibody sarilumab, when added to an evolving standard of care (SOC), for clinical management of inpatients with moderate to severe COVID-19 disease.DesignTwo-arm, randomized, open-label controlled trial compar

Chemical communication plays a key role in homeostasis within social insect societies.The development of the superorganism relies on the tightly regulated raising of new individuals, which necessitates an efficient communication Baby Gift Sets system between the brood and adult workers.In the honey bee Apis mellifera, a blend of ten fatty-acid este

This paper explores the Baby Bowl multiplicity of weak solutions to a class of weighted elliptic problems with variable exponents, incorporating a Hardy term and a nonlinear indefinite source term.Using critical point theory applied to the associated energy functional, we establish the existence of at least three weak solutions under general assump